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- Stan Hansen, professional wrestler
- Tully Blanchard, professional wrestler
- Ulane Bonnel, naval historian
- Ted DiBiase, professional wrestler
- Candace Camp, author
- Maurice Cheeks, NBA basketball player and coach
- Larry Combest, politician
- Jesse Cross, US Army general
- Dory Funk Jr., professional wrestler
- Terry Funk, professional wrestler
- J. Evetts Haley, historian and political activist
- Alondra Johnson, Canadian Football League football player
- Steve Kragthorpe, college football head coach
- Reggie McElroy, NFL American football player
- Jerry Logan, NFL American football player
- Mercury Morris, NFL American football player
- Georgia O'Keeffe, artist (faculty member)
- Kareem Larrimore, NFL American football player
- Ryan Leaf, NFL American football player and quarterbacks coach (faculty member)
- Anita Thigpen Perry, First Lady of Texas
- Donald Powell, former Chairman of the FDIC and Current Federal Coordinator of Gulf Coast Rebuilding
- Dusty Rhodes, professional wrestler
- Bruce Robison, hit country songwriter ("Travelin' Soldier", Angry All The Time, Desperately) and singer
- Marsha Sharp, women's basketball coach
- Stanley T. Sigman, AT&T Mobility CEO
- John T. Smithee, Texas state representative since 1985
- Tito Santana (Merced Solis), professional wrestler
- Red Steagall, country singer and Western poet
- French Stewart, actor
- Duane Thomas, NFL American football player
- Chaun Thompson, NFL American football player
- John Ayers, NFL American football player
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